Sacubitril/valsartan [Entresto™]
Sacubitril/valsartan [Entresto™] is a medication used in the treatment of certain forms of heart failure.
This combination includes two complementary mechanisms of action:
- sacubitril, which helps preserve certain substances beneficial to the heart and circulation
- valsartan, an angiotensin receptor blocker (ARB), which helps reduce the workload on the heart and bloodBlood is composed of red blood cells, white blood cells, platelets, and plasma. Red blood cells are responsible for transporting oxygen and carbon dioxide. White blood cells make up our immune defense system. Platelets contribute to blood vessels
This treatment is generally used as a replacement for an angiotensin-converting enzyme inhibitor (ACE inhibitor) or an ARB in patients who meet specific criteria, particularly when symptoms of heart failure persist despite already optimized therapy.
Studies have shown that this medication may:
- improve symptoms
- reduce hospitalizations related to heart failure
- lower the risk of cardiovascular complications in certain patients
Entresto™ is usually taken twice daily.
Possible side effects
The most commonly reported side effects include:
- dizziness
- low bloodBlood is composed of red blood cells, white blood cells, platelets, and plasma. Red blood cells are responsible for transporting oxygen and carbon dioxide. White blood cells make up our immune defense system. Platelets contribute to blood pressure
- fatigue or weakness
A cough may also occur in some individuals.
As with many medications used in heart failure, bloodBlood is composed of red blood cells, white blood cells, platelets, and plasma. Red blood cells are responsible for transporting oxygen and carbon dioxide. White blood cells make up our immune defense system. Platelets contribute to blood tests may be required to monitor:
- kidney function
- potassium levels
- response to treatment
In some patients, a significant drop in bloodBlood is composed of red blood cells, white blood cells, platelets, and plasma. Red blood cells are responsible for transporting oxygen and carbon dioxide. White blood cells make up our immune defense system. Platelets contribute to blood pressure may require an adjustment of the dosage or of other associated medications.
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