The cholesterol

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How much do you know about cholesterol?

Everyone talks about cholesterol, the good kind, then the bad kind that builds up fatty deposits on artery walls. However, very few people are aware of the vital role that good cholesterol plays in the human body.

Essential to Life

Present in every cell of the body, cholesterol is essential for the membrane, the outer skin of the cell, to ensure its integrity and functioning.

Cholesterol is necessary for the production of steroid hormones such as cortisol, aldosterone, and sex hormones like estrogen and testosterone.

Additionally, it plays a key role in the defense system against infections and in the production of bile acids, which are essential for digestion and the absorption process of fats in the intestine.

We All Manufacture and Eat Cholesterol

Cholesterol can be both important and dangerous simultaneously due to the balance and the level of cholesterol in the bloodstream. Let’s examine this further.

Firstly, let's consider the quantity.

Our body produces cholesterol every day, termed endogenous cholesterol because it is internally generated, primarily in the liver.

The amount produced varies from person to person and is genetically regulated by an internal manufacturing regulator or thermostat.

Another portion of cholesterol, known as exogenous cholesterol, comes from our diet.

It earns its name because it originates from outside the body. This cholesterol is absorbed by the intestine and then transported to the liver.

Transported in the Blood Circulation by “Taxi”

Cholesterol, both ingested and manufactured, is released into the bloodstream through carriers whose function can be compared to taxis. The “good taxi,” or good cholesterol, is known as HDL (High-Density Lipoprotein), while the “bad taxi,” or bad cholesterol, is referred to as LDL (Low-Density Lipoprotein).

LDL, which is produced and supplied by the diet, transports cholesterol from the liver to the body’s cells. Any excess is returned to the liver where it is eliminated by HDL, the good cholesterol.

Do you understand the importance of HDL, the good cholesterol?

The more you have, the better the elimination of the surplus.

Imprints in the Vessels

From birth, the process of cholesterol transportation begins and can leave traces on the artery walls.

Over time, these traces can evolve into cholesterol plaques, a phenomenon known as atherosclerosis.

Origin of the Cholesterol Plaques

The formation of plaques begins with the deposition of cholesterol, transported by LDL or the “bad taxi,” on the thin inner layer of the blood vessel called the intima.

Cholesterol is absorbed and stored in the muscular layer of the vessel called the media.

Its presence produces inflammation

This accumulation of cholesterol triggers inflammation.

Immune system cleaning cells, called macrophages, are attracted to this inflammation and absorb the cholesterol, but they become oversized and then trapped in the vessel wall.

When these cells die, they release their contents, including cholesterol, worsening the inflammation and contributing to the formation of new plaques.

This process can repeat itself, leading to an increase in the number and volume of plaques, depending on the amount of excess LDL cholesterol in the blood.

LDL Taxis Pollute Just As Much

The taxis of bad cholesterol (LDL) also contribute significantly to plaque formation. Indeed, the presence of certain proteins called apoproteins, which act as parts of the taxi, also induces inflammation comparable to pollution emitted by vehicles traveling on roads.

Researchers are currently investigating these proteins in order to design and develop medication that would reduce their numbers and reverse their impact on health.

What Causes Excess LDL?

Generally speaking, excess of bad cholesterol (LDL) comes from:

  • poor dietary habits, especially saturated fats;
  • predisposition (genetic or risk factors);
  • certain diseases (kidney, thyroid).

Reduction of Bad Cholesterol Is Possible

The reduction of bad cholesterol (LDL) can be achieved by respecting 2 principles:

  1. adopting better lifestyle habits:
  • balanced diet, low in saturated fats;
  • regular physical activity;
  • weight loss or maintenance of target weight.
  1. Medication

If improvement in lifestyle habits is insufficient in reducing the bad cholesterol (LDL), and if there is a predisposition, i.e. risk factors, to coronary artery disease, medication may be prescribed. In the case of coronary artery disease, the use of medication will be required.